Prevalence of very high cholesterol levels in asymptomatic military recruits: A single center study

Area of Science:

• Cardiology
• Public Health
• Genetics

Background:

• Familial hypercholesterolemia (FH) is a genetic disorder causing significantly elevated LDL-C.
• Elevated LDL-C increases the risk of premature atherosclerotic cardiovascular disease (ASCVD).
• FH is often underdiagnosed, particularly in asymptomatic populations.

Purpose of the Study:

• To determine the prevalence of very high LDL-C (≥4.9 mmol/L) in asymptomatic UAE military recruits.
• To identify potential undiagnosed cases of FH within this demographic.
• To inform early detection and management strategies for ASCVD risk.

Main Methods:

• A cross-sectional study involving 30,000 UAE national military recruits (aged 17-40).
• Routine lipid screening and review of electronic medical records (EMRs).
• Identification of individuals with LDL-C levels ≥4.9 mmol/L.

Main Results:

• 2% (596 recruits) presented with LDL-C levels ≥4.9 mmol/L.
• The mean age of affected recruits was 25 years.
• The majority of affected individuals were male (96.8%).

Conclusions:

• A significant prevalence of very high LDL-C was observed in young, asymptomatic UAE military recruits.
• This suggests a potential undiagnosed burden of FH in this population.
• Early genetic screening and intervention are recommended to mitigate ASCVD risk.