Advances in alginate-based nanoformulations: Innovative and effective strategies for targeting and treating brain disorders

Area of Science:

• Biomaterials Science
• Nanotechnology
• Neuroscience

Background:

• Brain disorders pose significant drug delivery challenges due to the blood-brain barrier (BBB) and poor therapeutic bioavailability.
• Alginate-derived nanoformulations offer biocompatibility, controlled release, and improved targeting for brain drug delivery.

Purpose of the Study:

• To review advancements in alginate-based nanoformulations for overcoming brain drug delivery obstacles.
• To explore the therapeutic potential of these nanoformulations for various neurological disorders.

Main Methods:

• Overview of alginate properties, applications, and limitations.
• Discussion of nanoformulation strategies (lipid-based, polymeric, inorganic) for cerebral targeting.
• Analysis of therapeutic efficacy for Alzheimer's disease, Parkinson's disease, brain tumors, TBI, epilepsy, and ALS.

Main Results:

• Alginate nanoformulations demonstrate significant potential for enhanced drug delivery to the brain.
• Various nanoformulation strategies can be employed to improve targeting and efficacy.
• These systems show promise across a spectrum of neurological conditions.

Conclusions:

• Alginate-based nanoformulations represent a promising avenue for developing effective brain-targeted therapies.
• Further research is needed to optimize nanocarriers for clinical application and address associated challenges.