Unveiling the antioxidant potential of new modified hyaluronan derivatives: Design, synthesis, characterization, antioxidant evaluation, and in-silico ADMET with molecular docking simulation

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Dermatology

Background:

• Hyaluronan (HA), a key extracellular matrix glycosaminoglycan, influences tissue structure and biological functions.
• Its network-forming ability and negative charge are vital for biochemical activities.
• Chemical modification of HA yields novel biocompatible and degradable materials.

Purpose of the Study:

• To synthesize and characterize novel aromatic derivatives of hyaluronan.
• To evaluate the antioxidant and anti-inflammatory potential of these derivatives.
• To explore their therapeutic applications in wound healing.

Main Methods:

• Synthesis of HA derivatives using 4-(Dimethylamino)benzaldehyde and 2',4',6'-Trihydroxyacetophenone.
• Characterization via Fourier transform infrared spectroscopy, electronic spectrum analysis, thermal gravimetric analysis, and differential scanning calorimetry.
• Assessment of free-radical scavenging activity using ABTS and DPPH assays, alongside molecular docking and pharmacokinetic studies.

Main Results:

• Successful formulation of novel aromatic hyaluronan derivatives.
• Demonstrated significant free-radical scavenging and antioxidant activities.
• Molecular docking and pharmacokinetic analyses elucidated antioxidant mechanisms and therapeutic potential.

Conclusions:

• The novel HA derivatives exhibit promising anti-inflammatory and antioxidant properties.
• These derivatives are suitable for developing specialized wound dressings.
• The developed wound dressings can combat pathogenic bacteria and facilitate chronic skin wound treatment.