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Recent advances in extracellular matrix-inspired nanocarriers | JoVE Visualize

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Recent advances in extracellular matrix-inspired nanocarriers

Sanjna Rao¹, Kristi L Kiick^1,2

¹Department of Biomedical Engineering, University of Delaware, Newark, DE, USA.

Expert Opinion on Drug Delivery|June 12, 2025

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View abstract on PubMed

Summary

Extracellular matrix (ECM)-inspired nanocarriers offer advanced drug delivery with enhanced efficacy and targeting. While promising, challenges in scalability and clinical data hinder widespread application.

Area of Science:

Biomaterials Science
Nanotechnology
Drug Delivery Systems

Background:

Extracellular matrix (ECM) plays a vital role in tissue function and homeostasis.
ECM-inspired nanocarriers leverage the ECM's complex structure for improved therapeutic delivery.
Traditional nanocarriers face limitations that ECM-inspired systems aim to overcome.

Purpose of the Study:

To review the design, fabrication, and applications of ECM-inspired nanocarriers.
To focus on nanocarriers derived from elastin, collagen, and hyaluronic acid.
To discuss benefits, challenges, and future directions in the field.

Main Methods:

Literature review of recent advancements (last 5 years) in ECM-inspired nanocarriers.
Analysis of nanocarriers based on specific ECM components (elastin, collagen, hyaluronic acid).
Examination of applications in drug delivery, tissue engineering, and regenerative medicine.

Main Results:

ECM-inspired nanocarriers demonstrate superior efficacy, targeting, and responsiveness.
Conjugate nanoparticles combining ECM components show significant potential.
Mimicking ECM structure enhances nanocarrier performance.

Conclusions:

ECM-inspired nanocarriers represent a novel platform for advanced therapeutics.
Significant progress in pre-clinical studies, but challenges in scalability and immunogenicity persist.
Further clinical data is required for translation into practice.

Keywords:

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Nanoelectronics

Recent Advances In Extracellular Matrix-inspired Nanocarriers

clinical translation

hyaluronic acid

targeted delivery

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