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  11. Curcumin's Multi-target Mechanisms In The Treatment Of Alzheimer's Disease And Creative Modification Techniques

Curcumin's multi-target mechanisms in the treatment of Alzheimer's disease and creative modification techniques

Xiaoyuan Meng1, Yong Gong2, Fengxin Xiao2

  • 1Key Laboratory of Tropical Translational Medicine of Ministry of Education & Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China.

Journal of Alzheimer'S Disease : JAD|May 21, 2025

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View abstract on PubMed

Summary

Curcumin shows promise for Alzheimer's disease (AD) treatment due to its anti-inflammatory and antioxidant effects. Novel derivatives and combination therapies aim to overcome curcumin's limitations for better AD management.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Natural Products

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder with increasing global prevalence.
  • Current treatments for AD face challenges due to the disease's complexity and limited therapeutic options.
  • Curcumin, a compound from turmeric, exhibits neuroprotective properties but has poor bioavailability.

Purpose of the Study:

  • To review the therapeutic potential of curcumin for Alzheimer's disease.
  • To explore the mechanisms of action of curcumin in AD.
  • To discuss strategies like curcumin derivatives and combination therapy to enhance efficacy.

Main Methods:

  • Literature review of studies on curcumin and Alzheimer's disease.
  • Analysis of curcumin's anti-inflammatory, antioxidant, and neuroprotective mechanisms.
  • Evaluation of research on curcumin derivatives and combination therapies for AD.

Main Results:

  • Curcumin demonstrates potential in inhibiting neuroinflammation, regulating tau hyperphosphorylation, and modulating amyloid-beta peptides.
  • Curcumin's antioxidant benefits contribute to its neuroprotective effects.
  • Synthesized curcumin derivatives and combination therapies show promise in overcoming bioavailability issues.

Conclusions:

  • Curcumin and its derivatives offer a promising therapeutic avenue for Alzheimer's disease.
  • Combination therapy strategies may enhance the effectiveness of curcumin-based treatments.
  • Further advancements in drug design are crucial for developing effective AD therapies.
Keywords:
Alzheimer's diseasecurcumininflammationmicroglia

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